The Meeting for Advanced Synthetic Biology and Systems Bioengineering in Vancouver (MASSIV) 1.0 will bring together leading researchers, innovators, and trainees from around the world to discuss the future of synthetic biology and biomedical engineering. Recent advances in genome, cell, tissue, and organ engineering have enabled us to push the boundaries of biology and medicine at an unprecedented scale. Hosted in Vancouver, MASSIV 1.0 will highlight cutting-edge technologies and applications at the interface of biology, engineering, and data science. We will place special emphasis on how long-standing synthetic biology and bioengineering principles, originally developed using microorganisms alongside computational and AI approaches, can now be applied to stem cell biology and tissue engineering to advance human health more than ever before.